Repair Outlook Data File - No data file to repair as Outlook never opened to create one. Disable Exchange cached mode - No differenceĥ. Run the resetnavpane command - did not fix the problemĤ. Create new Outlook Profile - Tried several times and still won't openģ. Start Outlook in Safe Mode - Still won't openĢ. Now, I've googled this extensively and have come up with several solutions that still won't fix my problemġ. The attempt to log on to Microsoft Exchange has failed.' Cannot open the Outlook Window.The set of folders cannot be opened. When I attempt to open Outlook, I get a message: We have our own on-premise Exchange 2013 server and not using Exchange Online. This is a Windows 10 Pro box, and the version of Office we use is 2019 Office 365 (Microsoft 365 Apps for Enterprise) I am preparing to give a user a new desktop computer and in the process of setting everything up on the new machine. I have a strange and unusual situation with Outlook today.